DegronMD

Uniprot ID: Q9Y5R2

Source protein: Matrix metalloproteinase-24

Source gene: MMP24

Class: DEG_MDM2_SWIB_1

Location: 397:405

E3 ligase: MDM2

DEGRON score: 0.7647

ASA_SCORE: 49.1222

COIL: 0.2841

CONS_SCORE: 0.4947

DSS_SCORE: 0.0558

HELIX: 0.0041

FCONS_SCORE: 1.2207

RIG_SCORE: 1.0069

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W403C	TCGA-DX-A6YS	SARC	TCGA	FKDRWFWRL	DEG_MDM2_SWIB_1	0.5889
p.W403C	DO220005	SARC	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.5889
p.E393K	DO222765	COCA	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.2222
p.W401C	DO228974	LICA	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.7
p.F390L	DO26957	LUSC	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.1389
p.E412K	DO220852	MELA	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.1389
p.R404C	DO218306	ORCA	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.719
p.G413D	DO229213	THCA	ICGC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.1111
p.R406C	SIDM00683	Prostate Carcinoma	GDSC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.3056
p.R406C	ACH-000977	lymph_node	CCLE	FKDRWFWRL	DEG_MDM2_SWIB_1	0.3056
p.R406C	LNCaP-Clone-FGC	prostate	COSMIC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.3056
p.R400H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.7133
p.R400H	ACH-002256	Leukemia	CCLE	FKDRWFWRL	DEG_MDM2_SWIB_1	0.7133
p.R400H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FKDRWFWRL	DEG_MDM2_SWIB_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5R2	Matrix metalloproteinase-24	DEG_MDM2_SWIB_1	397:405	FKDRWFWRL	MDM2	0.7647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons