DegronMD

Uniprot ID: P56705

Source protein: Protein Wnt-4

Source gene: WNT4

Class: LIG_APCC_ABBA_1

Location: 262:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5861

ASA_SCORE: 87.0333

COIL: 0.8887

CONS_SCORE: 0.514

DSS_SCORE: 0.4692

HELIX: 0.0785

FCONS_SCORE: 1.1265

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T266K	DO229022	LICA	ICGC	FKPHTD	LIG_APCC_ABBA_1	0.6195
p.S276R	DO229026	LICA	ICGC	FKPHTD	LIG_APCC_ABBA_1	0.0833
p.S276G	ACH-002027	Endometrial/Uterine Cancer	CCLE	FKPHTD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56705	Protein Wnt-4	LIG_APCC_ABBA_1	262:267	FKPHTD	APC,CDC20,FZR1	0.5861	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons