DegronMD

Uniprot ID: Q15047

Source protein: Histone-lysine N-methyltransferase SETDB1

Source gene: SETDB1

Class: LIG_APCC_ABBA_1

Location: 293:298

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 13.7667

COIL: 0.0672

CONS_SCORE: 0.7299

DSS_SCORE: 0.0305

HELIX: 0.0028

FCONS_SCORE: 1.3009

RIG_SCORE: 0.9882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P285Q	TCGA-09-2044	OV	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.1111
p.P285Q	DO28923	OV	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.1111
p.Q307L	TCGA-86-6562	LUAD	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.0833
p.Q307L	DO24013	LUAD	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.0833
p.D298Y	TCGA-A1-A0SO	BRCA	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.7325
p.K290T	TCGA-BR-8680	STAD	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.3611
p.K290T	DO47769	STAD	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.3611
p.D299Y	TCGA-D6-A4ZB	HNSC	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.3056
p.D299Y	DO44446	HNSC	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.3056
p.L294I	TCGA-EO-A22U	UCEC	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.6063
p.Y304C	TCGA-R8-A6MO	LGG	TCGA	FLIFFD	LIG_APCC_ABBA_1	0.1667
p.Y304C	DO48508	LGG	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.1667
p.V305F	DO228985	LICA	ICGC	FLIFFD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15047	Histone-lysine N-methyltransferase SETDB1	LIG_APCC_ABBA_1	293:298	FLIFFD	APC,CDC20,FZR1	0.5946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons