DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FLLLWALL
Uniprot ID:
P15813
Source protein:
Antigen-presenting glycoprotein CD1d
Source gene:
CD1D
Class:
DEG_MDM2_SWIB_1
Location:
6:13
E3 ligase:
MDM2
DEGRON score:
0.8649
ASA_SCORE:
83.3
COIL:
0.4074
CONS_SCORE:
0.605
DSS_SCORE:
0.0009
HELIX:
0.512
FCONS_SCORE:
1.4654
RIG_SCORE:
1.0478
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q23K
DO50894
LICA
ICGC
FLLLWALL
DEG_MDM2_SWIB_1
0.0556
p.A19V
DO222413
MELA
ICGC
FLLLWALL
DEG_MDM2_SWIB_1
0.1667
p.C3G
DO218908
SKCA
ICGC
FLLLWALL
DEG_MDM2_SWIB_1
0.25
p.Q14R
DO229211
THCA
ICGC
FLLLWALL
DEG_MDM2_SWIB_1
0.3056
p.A11V
DO42673
UCEC
ICGC
FLLLWALL
DEG_MDM2_SWIB_1
0.5825
p.A11E
SIDM00568
Gastric Carcinoma
GDSC
FLLLWALL
DEG_MDM2_SWIB_1
0.659
p.A11E
ACH-000247
Gastric Cancer
CCLE
FLLLWALL
DEG_MDM2_SWIB_1
0.659
Drug responses associated with CD1D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FLLLWALL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P15813
Antigen-presenting glycoprotein CD1d
DEG_MDM2_SWIB_1
6:13
FLLLWALL
MDM2
0.8649
More...