DegronMD

Uniprot ID: P15813

Source protein: Antigen-presenting glycoprotein CD1d

Source gene: CD1D

Class: DEG_MDM2_SWIB_1

Location: 6:13

E3 ligase: MDM2

DEGRON score: 0.8649

ASA_SCORE: 83.3

COIL: 0.4074

CONS_SCORE: 0.605

DSS_SCORE: 0.0009

HELIX: 0.512

FCONS_SCORE: 1.4654

RIG_SCORE: 1.0478

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A11E	SIDM00568	Gastric Carcinoma	GDSC	FLLLWALL	DEG_MDM2_SWIB_1	0.659
p.A11E	ACH-000247	Gastric Cancer	CCLE	FLLLWALL	DEG_MDM2_SWIB_1	0.659
p.A11V	DO42673	UCEC	ICGC	FLLLWALL	DEG_MDM2_SWIB_1	0.5825
p.Q14R	DO229211	THCA	ICGC	FLLLWALL	DEG_MDM2_SWIB_1	0.3056
p.C3G	DO218908	SKCA	ICGC	FLLLWALL	DEG_MDM2_SWIB_1	0.25
p.A19V	DO222413	MELA	ICGC	FLLLWALL	DEG_MDM2_SWIB_1	0.1667
p.Q23K	DO50894	LICA	ICGC	FLLLWALL	DEG_MDM2_SWIB_1	0.0556

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15813	Antigen-presenting glycoprotein CD1d	DEG_MDM2_SWIB_1	6:13	FLLLWALL	MDM2	0.8649	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons