DegronMD

Uniprot ID: P12956

Source protein: X-ray repair cross-complementing protein 6

Source gene: XRCC6

Class: LIG_APCC_ABBA_1

Location: 436:441

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6682

ASA_SCORE: 31.6

COIL: 0.582

CONS_SCORE: 0.7531

DSS_SCORE: 0.3115

HELIX: 0.0897

FCONS_SCORE: 1.5634

RIG_SCORE: 0.8562

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P430A	TCGA-39-5022	LUSC	TCGA	FLPFAD	LIG_APCC_ABBA_1	0.1667
p.P430A	DO27604	LUSC	ICGC	FLPFAD	LIG_APCC_ABBA_1	0.1667
p.G431C	TCGA-55-A491	LUAD	TCGA	FLPFAD	LIG_APCC_ABBA_1	0.1944
p.G431C	DO25787	LUAD	ICGC	FLPFAD	LIG_APCC_ABBA_1	0.1944
p.P438S	TCGA-AA-3715	COAD	TCGA	FLPFAD	LIG_APCC_ABBA_1	0.6752
p.P438S	DO8018	COAD	ICGC	FLPFAD	LIG_APCC_ABBA_1	0.6752
p.K443E	TCGA-AG-3906	READ	TCGA	FLPFAD	LIG_APCC_ABBA_1	0.7222
p.K443E	DO36491	READ	ICGC	FLPFAD	LIG_APCC_ABBA_1	0.7222
p.T428N	TCGA-B5-A1MX	UCEC	TCGA	FLPFAD	LIG_APCC_ABBA_1	0.5556
p.T428N	DO41999	UCEC	ICGC	FLPFAD	LIG_APCC_ABBA_1	0.5556
p.G431D	SIDM00082	Melanoma	GDSC	FLPFAD	LIG_APCC_ABBA_1	0.1944
p.G431D	SK-MEL-2	skin	COSMIC	FLPFAD	LIG_APCC_ABBA_1	0.1944
p.R429L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	FLPFAD	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12956	X-ray repair cross-complementing protein 6	LIG_APCC_ABBA_1	436:441	FLPFAD	APC,CDC20,FZR1	0.6682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons