DegronMD

Uniprot ID: O60304

Source protein: Zinc finger protein 500

Source gene: ZNF500

Class: DEG_MDM2_SWIB_1

Location: 215:222

E3 ligase: MDM2

DEGRON score: 0.9232

ASA_SCORE: 81.0875

COIL: 0.7269

CONS_SCORE: 0.7875

DSS_SCORE: 0.3354

HELIX: 0.2214

FCONS_SCORE: 1.343

RIG_SCORE: 0.7383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L226F	TCGA-22-5473	LUSC	TCGA	FLSAWSQV	DEG_MDM2_SWIB_1	0.2222
p.L226F	DO26467	LUSC	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.2222
p.V229M	TCGA-AP-A059	UCEC	TCGA	FLSAWSQV	DEG_MDM2_SWIB_1	0.1389
p.V229M	DO41361	UCEC	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.1389
p.S213L	TCGA-L5-A8NM	ESCA	TCGA	FLSAWSQV	DEG_MDM2_SWIB_1	0.2778
p.A210V	TCGA-VS-A94Z	CESC	TCGA	FLSAWSQV	DEG_MDM2_SWIB_1	0.1944
p.A210V	DO51634	CESC	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.1944
p.A210V	DO228138	PBCA	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.1944
p.Q221H	DO230342	COCA	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.647
p.L216F	DO222576	COCA	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.587
p.Q221L	DO228617	LICA	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.6654
p.V224L	DO230541	LUSC	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.2778
p.E227K	DO232761	PBCA	ICGC	FLSAWSQV	DEG_MDM2_SWIB_1	0.1944
p.Q221R	SIDM01016	T-Lymphoblastic Leukemia	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.6218
p.Q221R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.6218
p.Q221R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	FLSAWSQV	DEG_MDM2_SWIB_1	0.6218
p.R205Q	SIDM00086	Kidney Carcinoma	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.0556
p.R205Q	RXF393	kidney	COSMIC	FLSAWSQV	DEG_MDM2_SWIB_1	0.0556
p.V224M	SIDM00842	Colorectal Carcinoma	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.2778
p.V224M	SIDM00136	Colorectal Carcinoma	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.2778
p.V224M	SIDM00540	Oral Cavity Carcinoma	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.2778
p.Q221P	SIDM01450	Gastric Carcinoma	GDSC	FLSAWSQV	DEG_MDM2_SWIB_1	0.7035
p.W219S	ACH-000901	Lung Cancer	CCLE	FLSAWSQV	DEG_MDM2_SWIB_1	0.7874

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60304	Zinc finger protein 500	DEG_MDM2_SWIB_1	215:222	FLSAWSQV	MDM2	0.9232	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons