DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
FMVFID
Uniprot ID:
Q5VXH5
Source protein:
PRAME family member 7
Source gene:
PRAMEF7
Class:
LIG_APCC_ABBA_1
Location:
145:150
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5408
ASA_SCORE:
39.6
COIL:
0.2735
CONS_SCORE:
0.6689
DSS_SCORE:
0.1179
HELIX:
0.098
FCONS_SCORE:
1.4394
RIG_SCORE:
0.9515
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PRAMEF7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FMVFID
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5VXH5
PRAME family member 7
LIG_APCC_ABBA_1
145:150
FMVFID
APC,CDC20,FZR1
0.5408
More...