DegronMD

Uniprot ID: O95831

Source protein: Apoptosis-inducing factor 1, mitochondrial

Source gene: AIFM1

Class: LIG_APCC_ABBA_1

Location: 608:613

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9173

ASA_SCORE: 101.0833

COIL: 0.9203

CONS_SCORE: 0.3405

DSS_SCORE: 0.6661

HELIX: 0.0735

FCONS_SCORE: 1.0282

RIG_SCORE: 0.7936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A605D	TCGA-55-8506	LUAD	TCGA	FNIHED	LIG_APCC_ABBA_1	0.25
p.H598Y	TCGA-BG-A0MQ	UCEC	TCGA	FNIHED	LIG_APCC_ABBA_1	0.0556
p.H611Y	SIDM00938	Breast Carcinoma	GDSC	FNIHED	LIG_APCC_ABBA_1	0.6118
p.H611Y	ACH-000902	Breast Cancer	CCLE	FNIHED	LIG_APCC_ABBA_1	0.6118
p.H611Y	CAL-148	breast	COSMIC	FNIHED	LIG_APCC_ABBA_1	0.6118
p.H607Y	CAL-148	breast	COSMIC	FNIHED	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95831	Apoptosis-inducing factor 1, mitochondrial	LIG_APCC_ABBA_1	608:613	FNIHED	APC,CDC20,FZR1	0.9173	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons