DegronMD

Uniprot ID: Q9NXZ2

Source protein: Probable ATP-dependent RNA helicase DDX43

Source gene: DDX43

Class: DEG_MDM2_SWIB_1

Location: 221:228

E3 ligase: MDM2

DEGRON score: 0.572

ASA_SCORE: 61.9

COIL: 0.5801

CONS_SCORE: 0.3883

DSS_SCORE: 0.4195

HELIX: 0.0585

FCONS_SCORE: 0.9587

RIG_SCORE: 0.8391

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235T	TCGA-50-6594	LUAD	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.1389
p.P235T	DO24275	LUAD	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.1389
p.W216C	TCGA-A2-A0CL	BRCA	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.1944
p.W216C	DO2155	BRCA	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.1944
p.F221V	TCGA-BS-A0UF	UCEC	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.7068
p.F221V	DO41488	UCEC	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.7068
p.G231V	TCGA-DZ-6133	KIRP	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.25
p.G231V	DO20762	KIRP	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.25
p.K233E	TCGA-EE-A2MD	SKCM	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.3056
p.K233E	DO222434	MELA	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.3056
p.K233E	DO37851	SKCM	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.3056
p.T224S	TCGA-KK-A7B2	PRAD	TCGA	FNITWDDL	DEG_MDM2_SWIB_1	0.6005
p.T224S	DO51367	PRAD	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.6005
p.L228F	DO48384	BLCA	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.6981
p.K218R	DO225129	BRCA	ICGC	FNITWDDL	DEG_MDM2_SWIB_1	0.3611
p.T224A	SIDM01060	Melanoma	GDSC	FNITWDDL	DEG_MDM2_SWIB_1	0.6028
p.T224A	ACH-000882	Skin Cancer	CCLE	FNITWDDL	DEG_MDM2_SWIB_1	0.6028
p.T224A	IGR-1	skin	COSMIC	FNITWDDL	DEG_MDM2_SWIB_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NXZ2	Probable ATP-dependent RNA helicase DDX43	DEG_MDM2_SWIB_1	221:228	FNITWDDL	MDM2	0.572	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons