DegronMD

Uniprot ID: Q7Z398

Source protein: Zinc finger protein 550

Source gene: ZNF550

Class: DEG_MDM2_SWIB_1

Location: 212:219

E3 ligase: MDM2

DEGRON score: 0.6678

ASA_SCORE: 76.575

COIL: 0.6364

CONS_SCORE: 0.6634

DSS_SCORE: 0.1697

HELIX: 0.0629

FCONS_SCORE: 0.8566

RIG_SCORE: 0.8745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L221R	TCGA-EO-A22X	UCEC	TCGA	FNRKWYLV	DEG_MDM2_SWIB_1	0.2778
p.L221R	DO43907	UCEC	ICGC	FNRKWYLV	DEG_MDM2_SWIB_1	0.2778
p.R207W	DO230659	LAML	ICGC	FNRKWYLV	DEG_MDM2_SWIB_1	0.1944
p.T213I	ACH-000640	Skin Cancer	CCLE	FNRKWYLV	DEG_MDM2_SWIB_1	0.7078
p.T213I	SK-MEL-31	skin	COSMIC	FNRKWYLV	DEG_MDM2_SWIB_1	0.7078
p.C220S	NCI-H929	haematopoietic_and_lymphoid_tissue	COSMIC	FNRKWYLV	DEG_MDM2_SWIB_1	0.3056
p.H212Q	YKG-1	central_nervous_system	COSMIC	FNRKWYLV	DEG_MDM2_SWIB_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z398	Zinc finger protein 550	DEG_MDM2_SWIB_1	212:219	FNRKWYLV	MDM2	0.6678	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons