DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
FPMHRE
Uniprot ID:
Q9BU70
Source protein:
tRNA
Source gene:
TRMO
Class:
LIG_APCC_ABBA_1
Location:
244:249
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5442
ASA_SCORE:
84.8
COIL:
0.5815
CONS_SCORE:
0.146
DSS_SCORE:
0.4514
HELIX:
0.2982
FCONS_SCORE:
1.0298
RIG_SCORE:
0.7803
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I250M
SIDM00879
Breast Carcinoma
GDSC
FPMHRE
LIG_APCC_ABBA_1
0.3056
p.I250M
SIDM00006
Other Solid Cancers
GDSC
FPMHRE
LIG_APCC_ABBA_1
0.3056
Drug responses associated with TRMO mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FPMHRE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BU70
tRNA
LIG_APCC_ABBA_1
244:249
FPMHRE
APC,CDC20,FZR1
0.5442
More...