DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
FPPFPE
Uniprot ID:
Q86T03
Source protein:
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Source gene:
PIP4P1
Class:
LIG_APCC_ABBA_1
Location:
49:54
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9921
ASA_SCORE:
80.5
COIL:
0.9525
CONS_SCORE:
0.2707
DSS_SCORE:
0.5702
HELIX:
0.0188
FCONS_SCORE:
0.8659
RIG_SCORE:
0.6118
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PIP4P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FPPFPE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86T03
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
LIG_APCC_ABBA_1
49:54
FPPFPE
APC,CDC20,FZR1
0.9921
More...