DegronMD

Uniprot ID: Q99942

Source protein: E3 ubiquitin-protein ligase RNF5

Source gene: RNF5

Class: LIG_APCC_ABBA_1

Location: 111:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 61.75

COIL: 0.8472

CONS_SCORE: 0.3833

DSS_SCORE: 0.5883

HELIX: 0.0613

FCONS_SCORE: 0.9803

RIG_SCORE: 0.6511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A104T	TCGA-IB-7651	PAAD	TCGA	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.A104T	DO46657	PAAD	ICGC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.A104T	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.A104T	SIDM01728	Endometrial Carcinoma	GDSC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.A104T	SIDM01763	Rhabdomyosarcoma	GDSC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.A104T	SIDM01391	Neuroblastoma	GDSC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.S107G	DO45267	LIRI	ICGC	FQPFGD	LIG_APCC_ABBA_1	0.6667
p.S123A	DO227835	PBCA	ICGC	FQPFGD	LIG_APCC_ABBA_1	0.1389
p.R102I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	FQPFGD	LIG_APCC_ABBA_1	0.0833
p.R102I	ACH-000789	Lung Cancer	CCLE	FQPFGD	LIG_APCC_ABBA_1	0.0833
p.R102I	NCI-H810	lung	COSMIC	FQPFGD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99942	E3 ubiquitin-protein ligase RNF5	LIG_APCC_ABBA_1	111:116	FQPFGD	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons