DegronMD

Uniprot ID: Q9HBT7

Source protein: Zinc finger protein 287

Source gene: ZNF287

Class: DEG_MDM2_SWIB_1

Location: 156:164

E3 ligase: MDM2

DEGRON score: 0.8849

ASA_SCORE: 80.9667

COIL: 0.6637

CONS_SCORE: 0.3718

DSS_SCORE: 0.4354

HELIX: 0.27

FCONS_SCORE: 1.0015

RIG_SCORE: 0.7871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L164F	TCGA-09-2044	OV	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.6981
p.L164F	TCGA-21-1080	LUSC	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.6981
p.L164F	DO26502	LUSC	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.6981
p.L164F	DO28923	OV	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.6981
p.S169L	TCGA-AP-A056	UCEC	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	TCGA-AP-A0LM	UCEC	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	TCGA-BR-8680	STAD	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	TCGA-FI-A2D5	UCEC	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	DO47769	STAD	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	DO43306	UCEC	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	DO41331	UCEC	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.S169L	DO43971	UCEC	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.1944
p.T166A	TCGA-EO-A22R	UCEC	TCGA	FQTGWLNDL	DEG_MDM2_SWIB_1	0.2778
p.T166A	DO42713	UCEC	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.2778
p.A155V	DO230343	COCA	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.3056
p.G159V	DO228261	LICA	ICGC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.6421
p.D174H	SIDM00807	Bladder Carcinoma	GDSC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.0556
p.D174H	ACH-000905	Bladder Cancer	CCLE	FQTGWLNDL	DEG_MDM2_SWIB_1	0.0556
p.D174H	5637	urinary_tract	COSMIC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.0556
p.G152E	ACH-002396	Bone Cancer	CCLE	FQTGWLNDL	DEG_MDM2_SWIB_1	0.2222
p.G152E	Sarc9371	bone	COSMIC	FQTGWLNDL	DEG_MDM2_SWIB_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HBT7	Zinc finger protein 287	DEG_MDM2_SWIB_1	156:164	FQTGWLNDL	MDM2	0.8849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons