DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FQVTWAEV
Uniprot ID:
P23352
Source protein:
Anosmin-1
Source gene:
ANOS1
Class:
DEG_MDM2_SWIB_1
Location:
585:592
E3 ligase:
MDM2
DEGRON score:
0.593
ASA_SCORE:
25.575
COIL:
0.0736
CONS_SCORE:
0.4856
DSS_SCORE:
0.296
HELIX:
0.009
FCONS_SCORE:
1.2774
RIG_SCORE:
0.869
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T594M
SIDM01943
Colorectal Carcinoma
GDSC
FQVTWAEV
DEG_MDM2_SWIB_1
0.2778
Drug responses associated with ANOS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FQVTWAEV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P23352
Anosmin-1
DEG_MDM2_SWIB_1
585:592
FQVTWAEV
MDM2
0.593
More...