DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
FRIQLPCLS
Uniprot ID:
A0AVI2
Source protein:
Fer-1-like protein 5
Source gene:
FER1L5
Class:
DEG_APCC_DBOX_1
Location:
377:385
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6608
ASA_SCORE:
48.2556
COIL:
0.5476
CONS_SCORE:
0.3576
DSS_SCORE:
0.0214
HELIX:
0.0168
FCONS_SCORE:
0.8467
RIG_SCORE:
0.9338
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FER1L5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FRIQLPCLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A0AVI2
Fer-1-like protein 5
DEG_APCC_DBOX_1
377:385
FRIQLPCLS
APC,CDC20,FZR1
0.6608
More...