DegronMD

Uniprot ID: Q01780

Source protein: Exosome component 10

Source gene: EXOSC10

Class: DEG_APCC_DBOX_1

Location: 692:700

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6802

ASA_SCORE: 66.0889

COIL: 0.5203

CONS_SCORE: 0.2697

DSS_SCORE: 0.3551

HELIX: 0.3858

FCONS_SCORE: 1.0776

RIG_SCORE: 0.7578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V705I	TCGA-D1-A17M	UCEC	TCGA	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705I	DO233267	GACA	ICGC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705I	DO43779	UCEC	ICGC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705I	SIDM00151	Ovarian Carcinoma	GDSC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705I	ACH-000966	Ovarian Cancer	CCLE	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705I	IGROV-1	ovary	COSMIC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.V705D	DO222919	BTCA	ICGC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1944
p.D709Y	DO10880	GBM	ICGC	FRMFLPSLG	DEG_APCC_DBOX_1	0.0833
p.A708E	DO228952	LICA	ICGC	FRMFLPSLG	DEG_APCC_DBOX_1	0.1111
p.A709G	ACH-000811	Ovarian Cancer	CCLE	FRMFLPSLG	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01780	Exosome component 10	DEG_APCC_DBOX_1	692:700	FRMFLPSLG	APC,CDC20,FZR1	0.6802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons