DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FRPGLPEMA
Uniprot ID:
Q96PT3
Source protein:
Double homeobox protein 5
Source gene:
DUX5
Class:
DEG_APCC_DBOX_1
Location:
21:29
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6027
ASA_SCORE:
77.9556
COIL:
0.7943
CONS_SCORE:
0.5756
DSS_SCORE:
0.2896
HELIX:
0.1652
FCONS_SCORE:
0.9106
RIG_SCORE:
0.744
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DUX5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FRPGLPEMA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96PT3
Double homeobox protein 5
DEG_APCC_DBOX_1
21:29
FRPGLPEMA
APC,CDC20,FZR1
0.6027
More...