DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
FRPLLTIIE
Uniprot ID:
Q9Y4C0
Source protein:
Neurexin-3
Source gene:
NRXN3
Class:
DEG_APCC_DBOX_1
Location:
1367:1375
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8592
ASA_SCORE:
86.0889
COIL:
0.8026
CONS_SCORE:
0.2339
DSS_SCORE:
0.3605
HELIX:
0.0279
FCONS_SCORE:
1.0483
RIG_SCORE:
0.8444
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NRXN3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FRPLLTIIE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4C0
Neurexin-3
DEG_APCC_DBOX_1
1367:1375
FRPLLTIIE
APC,CDC20,FZR1
0.8592
More...