DegronMD

Uniprot ID: Q7Z2G1

Source protein: Histone H2B type W-T

Source gene: H2BW1

Class: DEG_APCC_DBOX_1

Location: 85:93

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6494

ASA_SCORE: 54.8222

COIL: 0.2448

CONS_SCORE: 0.742

DSS_SCORE: 0.1826

HELIX: 0.7324

FCONS_SCORE: 1.3547

RIG_SCORE: 0.8634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G78E	SIDM01398	Melanoma	GDSC	FRRVLKQVH	DEG_APCC_DBOX_1	0.1389
p.D79N	SIDM01104	Melanoma	GDSC	FRRVLKQVH	DEG_APCC_DBOX_1	0.1667
p.R86C	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	FRRVLKQVH	DEG_APCC_DBOX_1	0.8301
p.R77H	SIDM00220	Ovarian Carcinoma	GDSC	FRRVLKQVH	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2G1	Histone H2B type W-T	DEG_APCC_DBOX_1	85:93	FRRVLKQVH	APC,CDC20,FZR1	0.6494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons