DegronMD

Uniprot ID: Q01167

Source protein: Forkhead box protein K2

Source gene: FOXK2

Class: DEG_APCC_DBOX_1

Location: 358:366

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9875

ASA_SCORE: 83.9111

COIL: 0.8733

CONS_SCORE: 0.4007

DSS_SCORE: 0.5469

HELIX: 0.0424

FCONS_SCORE: 0.897

RIG_SCORE: 0.6801

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L362M	TCGA-29-1698	OV	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.711
p.L362M	TCGA-FS-A1Z0	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.711
p.L362M	DO28531	OV	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.711
p.L362M	DO37431	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.711
p.R359K	TCGA-AP-A1E0	UCEC	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.7237
p.R359K	DO43154	UCEC	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.7237
p.P364L	TCGA-CK-5916	COAD	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.6471
p.P364L	DO8786	COAD	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.6471
p.T360I	TCGA-D3-A8GR	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.7078
p.T360I	TCGA-FS-A1ZZ	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.7078
p.T360I	DO37412	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.7078
p.T360I	DO51247	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.7078
p.P361S	TCGA-DA-A95Z	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.5641
p.P361S	DO219481	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.5641
p.P374H	TCGA-EE-A2MD	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.1111
p.P374H	DO37851	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.1111
p.R353S	TCGA-ER-A19G	SKCM	TCGA	FRTPLGPLS	DEG_APCC_DBOX_1	0.1944
p.R353S	DO47284	SKCM	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.1944
p.L362V	DO224618	BRCA	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.6765
p.L362V	DO1016	BRCA	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.6765
p.V355M	DO220910	MELA	ICGC	FRTPLGPLS	DEG_APCC_DBOX_1	0.25
p.V355M	SIDM01043	Other Sarcomas	GDSC	FRTPLGPLS	DEG_APCC_DBOX_1	0.25
p.A372T	SIDM00220	Ovarian Carcinoma	GDSC	FRTPLGPLS	DEG_APCC_DBOX_1	0.1667
p.A372T	ACH-000962	Ovarian Cancer	CCLE	FRTPLGPLS	DEG_APCC_DBOX_1	0.1667
p.A372T	ACH-001145	Ovarian Cancer	CCLE	FRTPLGPLS	DEG_APCC_DBOX_1	0.1667
p.A372T	OC-314	ovary	COSMIC	FRTPLGPLS	DEG_APCC_DBOX_1	0.1667
p.L365F	SIDM01609	Endometrial Carcinoma	GDSC	FRTPLGPLS	DEG_APCC_DBOX_1	0.6981
p.L365F	ACH-000972	Endometrial/Uterine Cancer	CCLE	FRTPLGPLS	DEG_APCC_DBOX_1	0.6981
p.R353M	SIDM01451	Pancreatic Carcinoma	GDSC	FRTPLGPLS	DEG_APCC_DBOX_1	0.1944
p.R353M	ACH-000933	Pancreatic Cancer	CCLE	FRTPLGPLS	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRTPLGPLS

Degron related mutations and impact score

Drug responses associated with FOXK2 mutations

All proteins holding degron of FRTPLGPLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q01167	Forkhead box protein K2	DEG_APCC_DBOX_1	358:366	FRTPLGPLS	APC,CDC20,FZR1	0.9875	More...