DegronMD

Uniprot ID: Q16787

Source protein: Laminin subunit alpha-3

Source gene: LAMA3

Class: DEG_APCC_DBOX_1

Location: 785:793

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6276

ASA_SCORE: 22.4

COIL: 0.1306

CONS_SCORE: 0.4437

DSS_SCORE: 0.1299

HELIX: 0.0036

FCONS_SCORE: 1.4236

RIG_SCORE: 0.9061

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I788L	TCGA-25-2400	OV	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.6063
p.I788L	DO28053	OV	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.6063
p.G795E	TCGA-38-6178	LUAD	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.G795E	DO23842	LUAD	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.G795E	DO220877	MELA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.L789M	TCGA-AP-A1DV	UCEC	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.711
p.L789M	DO43186	UCEC	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.711
p.R786S	TCGA-CM-6171	COAD	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.7427
p.R786S	DO8151	COAD	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.7427
p.R786C	TCGA-CV-5442	HNSC	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.8301
p.R786C	DO14678	HNSC	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.8301
p.R786C	SIDM00337	Melanoma	GDSC	FRVILRYVN	DEG_APCC_DBOX_1	0.8301
p.R786C	ACH-000450	Skin Cancer	CCLE	FRVILRYVN	DEG_APCC_DBOX_1	0.8301
p.R786C	MEL-HO	skin	COSMIC	FRVILRYVN	DEG_APCC_DBOX_1	0.8301
p.Y791F	TCGA-DU-5852	LGG	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.6417
p.Y791F	DO22171	LGG	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.6417
p.S783F	TCGA-EB-A5UM	SKCM	TCGA	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.S783F	DO47282	SKCM	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.E803Q	DO456	BLCA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.0556
p.S781G	DO1138	BRCA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.2222
p.T796N	DO229010	COCA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.25
p.T796N	DO229013	COCA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.25
p.T796N	DO229346	LAML	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.25
p.G795R	DO233730	GACA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.2778
p.V792F	DO229029	LICA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.7068
p.R786L	DO229032	LICA	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.8428
p.G800W	DO37444	SKCM	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.1389
p.G800W	DO37951	SKCM	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.1389
p.D782N	DO38153	SKCM	ICGC	FRVILRYVN	DEG_APCC_DBOX_1	0.25
p.E803K	HSC-3	upper_aerodigestive_tract	COSMIC	FRVILRYVN	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRVILRYVN

Degron related mutations and impact score

Drug responses associated with LAMA3 mutations

All proteins holding degron of FRVILRYVN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16787	Laminin subunit alpha-3	DEG_APCC_DBOX_1	785:793	FRVILRYVN	APC,CDC20,FZR1	0.6276	More...