DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FTCFWAGCV
Uniprot ID:
Q8NBF1
Source protein:
Zinc finger protein GLIS1
Source gene:
GLIS1
Class:
DEG_MDM2_SWIB_1
Location:
229:237
E3 ligase:
MDM2
DEGRON score:
0.8857
ASA_SCORE:
52.1222
COIL:
0.5803
CONS_SCORE:
0.592
DSS_SCORE:
0.0575
HELIX:
0.0524
FCONS_SCORE:
1.2733
RIG_SCORE:
0.9252
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R224S
TCGA-A6-3810
COAD
TCGA
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1944
p.R224S
DO9434
COAD
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1944
p.P242L
TCGA-AP-A0LM
UCEC
TCGA
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1944
p.P242L
DO43306
UCEC
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1944
p.G226S
TCGA-D3-A8GC
SKCM
TCGA
FTCFWAGCV
DEG_MDM2_SWIB_1
0.25
p.G226S
DO50281
SKCM
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.25
p.K225N
TCGA-FD-A3B3
BLCA
TCGA
FTCFWAGCV
DEG_MDM2_SWIB_1
0.3333
p.K225N
DO749
BLCA
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.3333
p.A245V
TCGA-QB-AA9O
SKCM
TCGA
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1111
p.A245V
DO51267
SKCM
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1111
p.V237M
DO233855
GACA
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.7208
p.D222E
DO229024
LICA
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1389
p.N244K
DO229026
LICA
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1389
p.R238S
DO229032
LICA
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.3056
p.S219R
DO50799
LIRI
ICGC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.0556
p.Y240C
SIDM00773
Non-Cancerous
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.Y240C
SIDM00454
Rhabdomyosarcoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.Y240C
SIDM00849
Kidney Carcinoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.Y240C
SIDM00721
Small Cell Lung Carcinoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.Y240C
SIDM00774
Breast Carcinoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.Y240C
SIDM01173
Rhabdomyosarcoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6944
p.V237A
SIDM00761
Small Cell Lung Carcinoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6936
p.V237A
ACH-000752
Lung Cancer
CCLE
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6936
p.V237A
NCI-H196
lung
COSMIC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.6936
p.R246C
SIDM00282
Colorectal Carcinoma
GDSC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.0833
p.R246C
ACH-000998
Colon/Colorectal Cancer
CCLE
FTCFWAGCV
DEG_MDM2_SWIB_1
0.0833
p.R246C
CW-2
large_intestine
COSMIC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.0833
p.P246T
Sarc9371
bone
COSMIC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.0833
p.G223D
NCI-H810
lung
COSMIC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.1667
p.P233R
CHSA0108
bone
COSMIC
FTCFWAGCV
DEG_MDM2_SWIB_1
0.7512
Drug responses associated with GLIS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FTCFWAGCV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NBF1
Zinc finger protein GLIS1
DEG_MDM2_SWIB_1
229:237
FTCFWAGCV
MDM2
0.8857
More...