DegronMD

Uniprot ID: Q86SR1

Source protein: Polypeptide N-acetylgalactosaminyltransferase 10

Source gene: GALNT10

Class: DEG_MDM2_SWIB_1

Location: 503:511

E3 ligase: MDM2

DEGRON score: 0.5958

ASA_SCORE: 41.1111

COIL: 0.427

CONS_SCORE: 0.6238

DSS_SCORE: 0.3404

HELIX: 0.029

FCONS_SCORE: 1.3753

RIG_SCORE: 0.8978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R512Q	TCGA-A5-A0G2	UCEC	TCGA	FTFTWREDI	DEG_MDM2_SWIB_1	0.3056
p.R512Q	DO41235	UCEC	ICGC	FTFTWREDI	DEG_MDM2_SWIB_1	0.3056
p.I511V	TCGA-DI-A1BU	UCEC	TCGA	FTFTWREDI	DEG_MDM2_SWIB_1	0.5965
p.I511V	DO42023	UCEC	ICGC	FTFTWREDI	DEG_MDM2_SWIB_1	0.5965
p.W507C	TCGA-F7-A624	HNSC	TCGA	FTFTWREDI	DEG_MDM2_SWIB_1	0.7
p.W507C	DO44440	HNSC	ICGC	FTFTWREDI	DEG_MDM2_SWIB_1	0.7
p.E509D	TCGA-HC-7233	PRAD	TCGA	FTFTWREDI	DEG_MDM2_SWIB_1	0.5647
p.E509D	DO46813	PRAD	ICGC	FTFTWREDI	DEG_MDM2_SWIB_1	0.5647
p.A495S	DO50672	ORCA	ICGC	FTFTWREDI	DEG_MDM2_SWIB_1	0.1111
p.F503C	SIDM00541	Colorectal Carcinoma	GDSC	FTFTWREDI	DEG_MDM2_SWIB_1	0.7108
p.F503C	ACH-000926	Colon/Colorectal Cancer	CCLE	FTFTWREDI	DEG_MDM2_SWIB_1	0.7108
p.F503C	HT55	large_intestine	COSMIC	FTFTWREDI	DEG_MDM2_SWIB_1	0.7108
p.A496S	ACH-001802	Liposarcoma	CCLE	FTFTWREDI	DEG_MDM2_SWIB_1	0.1389
p.M502L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	FTFTWREDI	DEG_MDM2_SWIB_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86SR1	Polypeptide N-acetylgalactosaminyltransferase 10	DEG_MDM2_SWIB_1	503:511	FTFTWREDI	MDM2	0.5958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons