DegronMD

Uniprot ID: Q9BU70

Source protein: tRNA

Source gene: TRMO

Class: LIG_APCC_ABBA_1

Location: 341:346

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7461

ASA_SCORE: 51.4

COIL: 0.2438

CONS_SCORE: 0.4648

DSS_SCORE: 0.354

HELIX: 0.6525

FCONS_SCORE: 1.1825

RIG_SCORE: 0.8152

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R340Q	SIDM02013	Colorectal Carcinoma	GDSC	FTPHAE	LIG_APCC_ABBA_1	0.3056
p.R340W	SIDM00217	Colorectal Carcinoma	GDSC	FTPHAE	LIG_APCC_ABBA_1	0.3056
p.R340W	SNU-1040	large_intestine	COSMIC	FTPHAE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BU70	tRNA	LIG_APCC_ABBA_1	341:346	FTPHAE	APC,CDC20,FZR1	0.7461	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons