DegronMD

Uniprot ID: Q9UKG4

Source protein: Solute carrier family 13 member 4

Source gene: SLC13A4

Class: DEG_MDM2_SWIB_1

Location: 329:336

E3 ligase: MDM2

DEGRON score: 0.5374

ASA_SCORE: 105.425

COIL: 0.2331

CONS_SCORE: 0.6013

DSS_SCORE: 0.001

HELIX: 0.7533

FCONS_SCORE: 1.1925

RIG_SCORE: 1.0931

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C344S	TCGA-UB-A7MB	LIHC	TCGA	FWMHWLFL	DEG_MDM2_SWIB_1	0.1111
p.C344S	DO52318	LIHC	ICGC	FWMHWLFL	DEG_MDM2_SWIB_1	0.1111
p.L334M	DO229045	LICA	ICGC	FWMHWLFL	DEG_MDM2_SWIB_1	0.5999
p.S327N	DO229056	LICA	ICGC	FWMHWLFL	DEG_MDM2_SWIB_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKG4	Solute carrier family 13 member 4	DEG_MDM2_SWIB_1	329:336	FWMHWLFL	MDM2	0.5374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons