DegronMD

Uniprot ID: P40939

Source protein: Trifunctional enzyme subunit alpha, mitochondrial

Source gene: HADHA

Class: LIG_APCC_ABBA_1

Location: 636:641

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5107

ASA_SCORE: 76.0333

COIL: 0.5308

CONS_SCORE: 0.553

DSS_SCORE: 0.2592

HELIX: 0.0048

FCONS_SCORE: 1.0971

RIG_SCORE: 0.8476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I638V	TCGA-BA-6870	HNSC	TCGA	FYIYQE	LIG_APCC_ABBA_1	0.5965
p.I638V	DO15615	HNSC	ICGC	FYIYQE	LIG_APCC_ABBA_1	0.5965
p.Q640H	TCGA-DF-A2KN	UCEC	TCGA	FYIYQE	LIG_APCC_ABBA_1	0.647
p.Q640H	DO223282	UCEC	ICGC	FYIYQE	LIG_APCC_ABBA_1	0.647
p.K646N	SIDM00282	Colorectal Carcinoma	GDSC	FYIYQE	LIG_APCC_ABBA_1	0.6389
p.K646N	ACH-000998	Colon/Colorectal Cancer	CCLE	FYIYQE	LIG_APCC_ABBA_1	0.6389
p.K646N	CW-2	large_intestine	COSMIC	FYIYQE	LIG_APCC_ABBA_1	0.6389
p.R645S	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	FYIYQE	LIG_APCC_ABBA_1	0.2222
p.R645S	ACH-000826	Lung Cancer	CCLE	FYIYQE	LIG_APCC_ABBA_1	0.2222
p.R645S	CAL-12T	lung	COSMIC	FYIYQE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P40939	Trifunctional enzyme subunit alpha, mitochondrial	LIG_APCC_ABBA_1	636:641	FYIYQE	APC,CDC20,FZR1	0.5107	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons