DegronMD

Uniprot ID: Q96N20

Source protein: Zinc finger protein 75A

Source gene: ZNF75A

Class: DEG_APCC_KENBOX_2

Location: 112:116

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8885

ASA_SCORE: 101.88

COIL: 0.768

CONS_SCORE: 0.9445

DSS_SCORE: 0.5356

HELIX: 0.1546

FCONS_SCORE: 1.0947

RIG_SCORE: 0.6711

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H126L	TCGA-22-1002	LUSC	TCGA	GKENH	DEG_APCC_KENBOX_2	0.0556
p.H126L	DO26429	LUSC	ICGC	GKENH	DEG_APCC_KENBOX_2	0.0556
p.M119I	TCGA-AA-3811	COAD	TCGA	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	TCGA-AO-A128	BRCA	TCGA	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	TCGA-BR-4184	STAD	TCGA	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	DO5326	BRCA	ICGC	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	DO7962	COAD	ICGC	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	DO38328	STAD	ICGC	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	SIDM00333	Endometrial Carcinoma	GDSC	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	ACH-000988	Endometrial/Uterine Cancer	CCLE	GKENH	DEG_APCC_KENBOX_2	0.25
p.M119I	MFE-319	endometrium	COSMIC	GKENH	DEG_APCC_KENBOX_2	0.25
p.F117C	TCGA-BR-6564	STAD	TCGA	GKENH	DEG_APCC_KENBOX_2	0.3056
p.F117C	DO38229	STAD	ICGC	GKENH	DEG_APCC_KENBOX_2	0.3056
p.A111T	TCGA-DC-6682	READ	TCGA	GKENH	DEG_APCC_KENBOX_2	0.3056
p.A111T	DO37162	READ	ICGC	GKENH	DEG_APCC_KENBOX_2	0.3056
p.H116Y	TCGA-EE-A2MS	SKCM	TCGA	GKENH	DEG_APCC_KENBOX_2	0.6118
p.H116Y	DO37567	SKCM	ICGC	GKENH	DEG_APCC_KENBOX_2	0.6118
p.E114Q	TCGA-MN-A4N4	LUAD	TCGA	GKENH	DEG_APCC_KENBOX_2	0.6744
p.E114Q	DO26250	LUAD	ICGC	GKENH	DEG_APCC_KENBOX_2	0.6744
p.D118Y	DO229026	LICA	ICGC	GKENH	DEG_APCC_KENBOX_2	0.2778
p.G123V	DO23222	LINC	ICGC	GKENH	DEG_APCC_KENBOX_2	0.1389
p.K105T	SIDM01286	Esophageal Carcinoma	GDSC	GKENH	DEG_APCC_KENBOX_2	0.25
p.P107S	ACH-001515	Cervical Cancer	CCLE	GKENH	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N20	Zinc finger protein 75A	DEG_APCC_KENBOX_2	112:116	GKENH	APC,CDC20,FZR1	0.8885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons