DegronMD

Uniprot ID: Q8WUX9

Source protein: Charged multivesicular body protein 7

Source gene: CHMP7

Class: DEG_SIAH_1

Location: 226:234

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9637

ASA_SCORE: 82.6111

COIL: 0.909

CONS_SCORE: 0.5822

DSS_SCORE: 0.2993

HELIX: 0.0298

FCONS_SCORE: 0.8778

RIG_SCORE: 0.7147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R228H	TCGA-AP-A0LM	UCEC	TCGA	GPRAKVSPV	DEG_SIAH_1	0.7133
p.R228H	DO43306	UCEC	ICGC	GPRAKVSPV	DEG_SIAH_1	0.7133
p.I220N	DO52479	COCA	ICGC	GPRAKVSPV	DEG_SIAH_1	0.1667
p.K222N	DO229037	LICA	ICGC	GPRAKVSPV	DEG_SIAH_1	0.3333
p.K222R	DO45069	LINC	ICGC	GPRAKVSPV	DEG_SIAH_1	0.3333
p.V237I	DO232761	PBCA	ICGC	GPRAKVSPV	DEG_SIAH_1	0.25
p.A229T	SIDM01611	Endometrial Carcinoma	GDSC	GPRAKVSPV	DEG_SIAH_1	0.7139
p.A229T	ACH-000996	Endometrial/Uterine Cancer	CCLE	GPRAKVSPV	DEG_SIAH_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUX9	Charged multivesicular body protein 7	DEG_SIAH_1	226:234	GPRAKVSPV	SIAH1,SIAH2,SIAH3	0.9637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons