DegronMD

Uniprot ID: P04406

Source protein: Glyceraldehyde-3-phosphate dehydrogenase

Source gene: GAPDH

Class: DEG_APCC_DBOX_1

Location: 199:207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8747

ASA_SCORE: 44.6111

COIL: 0.7019

CONS_SCORE: 0.7477

DSS_SCORE: 0.4009

HELIX: 0.1781

FCONS_SCORE: 0.9415

RIG_SCORE: 0.7778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R200L	TCGA-DR-A0ZM	CESC	TCGA	GRGALQNII	DEG_APCC_DBOX_1	0.8428
p.P208T	TCGA-EE-A3AC	SKCM	TCGA	GRGALQNII	DEG_APCC_DBOX_1	0.3056
p.P208T	TCGA-FS-A1ZD	SKCM	TCGA	GRGALQNII	DEG_APCC_DBOX_1	0.3056
p.T211A	TCGA-KB-A6F7	STAD	TCGA	GRGALQNII	DEG_APCC_DBOX_1	0.6667
p.S209F	DO218611	BRCA	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.2778
p.S217A	DO11447	GBM	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.0556
p.S209C	DO52048	HNSC	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.2778
p.S191L	DO48884	LUAD	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.1111
p.L195P	DO47168	RECA	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.2222
p.H216Y	DO228014	SKCA	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.0833
p.G193S	DO229470	SKCA	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.1667
p.G200C	DO229216	THCA	ICGC	GRGALQNII	DEG_APCC_DBOX_1	0.76
p.I207V	SIDM01424	B-Lymphoblastic Leukemia	GDSC	GRGALQNII	DEG_APCC_DBOX_1	0.5965
p.I207V	ACH-000782	Leukemia	CCLE	GRGALQNII	DEG_APCC_DBOX_1	0.5965
p.I207V	ACH-001735	Leukemia	CCLE	GRGALQNII	DEG_APCC_DBOX_1	0.5965
p.P194S	451Lu	skin	COSMIC	GRGALQNII	DEG_APCC_DBOX_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04406	Glyceraldehyde-3-phosphate dehydrogenase	DEG_APCC_DBOX_1	199:207	GRGALQNII	APC,CDC20,FZR1	0.8747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons