DegronMD

Uniprot ID: Q9P0L1

Source protein: Zinc finger protein with KRAB and SCAN domains 7

Source gene: ZKSCAN7

Class: DEG_APCC_DBOX_1

Location: 5:13

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9993

ASA_SCORE: 72.1111

COIL: 0.8087

CONS_SCORE: 0.6814

DSS_SCORE: 0.6567

HELIX: 0.0919

FCONS_SCORE: 1.2045

RIG_SCORE: 0.7073

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P13L	SIDM01943	Colorectal Carcinoma	GDSC	GRGNLGLIP	DEG_APCC_DBOX_1	0.6471
p.P13T	SIDM01943	Colorectal Carcinoma	GDSC	GRGNLGLIP	DEG_APCC_DBOX_1	0.5919
p.N8D	TCGA-DI-A1BU	UCEC	TCGA	GRGNLGLIP	DEG_APCC_DBOX_1	0.5821
p.N8D	DO42023	UCEC	ICGC	GRGNLGLIP	DEG_APCC_DBOX_1	0.5821
p.S15N	DO2706	BRCA	ICGC	GRGNLGLIP	DEG_APCC_DBOX_1	0.2778

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P0L1	Zinc finger protein with KRAB and SCAN domains 7	DEG_APCC_DBOX_1	5:13	GRGNLGLIP	APC,CDC20,FZR1	0.9993	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons