DegronMD

Uniprot ID: Q8IVB5

Source protein: LIX1-like protein

Source gene: LIX1L

Class: DEG_APCC_DBOX_1

Location: 17:25

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9289

ASA_SCORE: 68.2556

COIL: 0.5413

CONS_SCORE: 0.3885

DSS_SCORE: 0.6592

HELIX: 0.3202

FCONS_SCORE: 1.0439

RIG_SCORE: 0.683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V28M	DO228904	LICA	ICGC	GRGTLRALR	DEG_APCC_DBOX_1	0.25
p.R22Q	DO229479	SKCA	ICGC	GRGTLRALR	DEG_APCC_DBOX_1	0.6218
p.G30A	SIDM00032	Bladder Carcinoma	GDSC	GRGTLRALR	DEG_APCC_DBOX_1	0.1944
p.G30A	ACH-000839	Bladder Cancer	CCLE	GRGTLRALR	DEG_APCC_DBOX_1	0.1944
p.L9Q	SIDM00208	Glioblastoma	GDSC	GRGTLRALR	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVB5	LIX1-like protein	DEG_APCC_DBOX_1	17:25	GRGTLRALR	APC,CDC20,FZR1	0.9289	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons