DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
GRKELKIVI
Uniprot ID:
Q9HBH0
Source protein:
Rho-related GTP-binding protein RhoF
Source gene:
RHOF
Class:
DEG_APCC_DBOX_1
Location:
16:24
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6267
ASA_SCORE:
56.7556
COIL:
0.3751
CONS_SCORE:
0.4798
DSS_SCORE:
0.3574
HELIX:
0.02
FCONS_SCORE:
0.9602
RIG_SCORE:
0.8126
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.I29L
MHH-CALL-2
haematopoietic_and_lymphoid_tissue
COSMIC
GRKELKIVI
DEG_APCC_DBOX_1
0.1944
Drug responses associated with RHOF mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRKELKIVI
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HBH0
Rho-related GTP-binding protein RhoF
DEG_APCC_DBOX_1
16:24
GRKELKIVI
APC,CDC20,FZR1
0.6267
More...