DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GRPGLPPLP
Uniprot ID:
Q06418
Source protein:
Tyrosine-protein kinase receptor TYRO3
Source gene:
TYRO3
Class:
DEG_APCC_DBOX_1
Location:
8:16
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7146
ASA_SCORE:
94.9667
COIL:
0.9759
CONS_SCORE:
0.3316
DSS_SCORE:
0.5365
HELIX:
0.0077
FCONS_SCORE:
0.963
RIG_SCORE:
0.5943
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TYRO3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRPGLPPLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q06418
Tyrosine-protein kinase receptor TYRO3
DEG_APCC_DBOX_1
8:16
GRPGLPPLP
APC,CDC20,FZR1
0.7146
More...