DegronMD

Uniprot ID: P24928

Source protein: DNA-directed RNA polymerase II subunit RPB1

Source gene: POLR2A

Class: DEG_APCC_DBOX_1

Location: 50:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9334

ASA_SCORE: 41.9556

COIL: 0.706

CONS_SCORE: 0.5341

DSS_SCORE: 0.6355

HELIX: 0.0311

FCONS_SCORE: 1.1034

RIG_SCORE: 0.6809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P60A	TCGA-A4-8098	KIRP	TCGA	GRPKLGGLM	DEG_APCC_DBOX_1	0.2778
p.P60A	DO20881	KIRP	ICGC	GRPKLGGLM	DEG_APCC_DBOX_1	0.2778
p.R51P	TCGA-F7-7848	HNSC	TCGA	GRPKLGGLM	DEG_APCC_DBOX_1	0.7512
p.R51P	DO14198	HNSC	ICGC	GRPKLGGLM	DEG_APCC_DBOX_1	0.7512
p.P60Q	TCGA-FS-A1Z0	SKCM	TCGA	GRPKLGGLM	DEG_APCC_DBOX_1	0.2778
p.P60Q	DO37431	SKCM	ICGC	GRPKLGGLM	DEG_APCC_DBOX_1	0.2778
p.P52L	TCGA-YD-A89C	SKCM	TCGA	GRPKLGGLM	DEG_APCC_DBOX_1	0.6471
p.P52L	DO219501	SKCM	ICGC	GRPKLGGLM	DEG_APCC_DBOX_1	0.6471
p.M58I	SIDM00375	Head and Neck Carcinoma	GDSC	GRPKLGGLM	DEG_APCC_DBOX_1	0.6507
p.M58I	ACH-002305	Head and Neck Cancer	CCLE	GRPKLGGLM	DEG_APCC_DBOX_1	0.6507
p.M58I	SKN-3	upper_aerodigestive_tract	COSMIC	GRPKLGGLM	DEG_APCC_DBOX_1	0.6507
p.T46M	SIDM01088	Endometrial Carcinoma	GDSC	GRPKLGGLM	DEG_APCC_DBOX_1	0.6667
p.T46M	ACH-000965	Endometrial/Uterine Cancer	CCLE	GRPKLGGLM	DEG_APCC_DBOX_1	0.6667
p.T46M	RL95-2	endometrium	COSMIC	GRPKLGGLM	DEG_APCC_DBOX_1	0.6667
p.I65T	ACH-001793	Liposarcoma	CCLE	GRPKLGGLM	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P24928	DNA-directed RNA polymerase II subunit RPB1	DEG_APCC_DBOX_1	50:58	GRPKLGGLM	APC,CDC20,FZR1	0.9334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons