DegronMD

Uniprot ID: Q9HCC6

Source protein: Transcription factor HES-4

Source gene: HES4

Class: DEG_APCC_DBOX_1

Location: 175:183

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9768

ASA_SCORE: 70.6333

COIL: 0.9172

CONS_SCORE: 0.5026

DSS_SCORE: 0.318

HELIX: 0.023

FCONS_SCORE: 1.1852

RIG_SCORE: 0.6739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R167L	DO229268	THCA	ICGC	GRPLLPSLG	DEG_APCC_DBOX_1	0.1111
p.E192D	SIDM02041	Colorectal Carcinoma	GDSC	GRPLLPSLG	DEG_APCC_DBOX_1	0.0833
p.G167R	SIDM00332	Breast Carcinoma	GDSC	GRPLLPSLG	DEG_APCC_DBOX_1	0.1111
p.R176S	ACH-000964	Leukemia	CCLE	GRPLLPSLG	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCC6	Transcription factor HES-4	DEG_APCC_DBOX_1	175:183	GRPLLPSLG	APC,CDC20,FZR1	0.9768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons