DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_APCC_DBOX_1

Location: 1492:1500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.886

ASA_SCORE: 100.6333

COIL: 0.5506

CONS_SCORE: 0.4824

DSS_SCORE: 0.717

HELIX: 0.3933

FCONS_SCORE: 1.2742

RIG_SCORE: 0.6696

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1504L	TCGA-20-0991	OV	TCGA	GRRELEMLS	DEG_APCC_DBOX_1	0.2222
p.S1504L	DO31949	OV	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.2222
p.E1497K	TCGA-56-7221	LUSC	TCGA	GRRELEMLS	DEG_APCC_DBOX_1	0.591
p.E1497K	DO26689	LUSC	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.591
p.S1484F	TCGA-AP-A1DK	UCEC	TCGA	GRRELEMLS	DEG_APCC_DBOX_1	0.1111
p.S1484F	DO42033	UCEC	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.1111
p.S1500P	TCGA-CD-A4MG	STAD	TCGA	GRRELEMLS	DEG_APCC_DBOX_1	0.5641
p.S1500P	DO48009	STAD	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.5641
p.S1501I	TCGA-OR-A5KB	ACC	TCGA	GRRELEMLS	DEG_APCC_DBOX_1	0.3056
p.L1486F	DO48386	BLCA	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.1667
p.P1506L	DO225284	BRCA	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.1667
p.D1505H	DO223379	CLLE	ICGC	GRRELEMLS	DEG_APCC_DBOX_1	0.1944
p.S1507C	ACH-001536	Bile Duct Cancer	CCLE	GRRELEMLS	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_APCC_DBOX_1	1492:1500	GRRELEMLS	APC,CDC20,FZR1	0.886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons