DegronMD

Uniprot ID: O60674

Source protein: Tyrosine-protein kinase JAK2

Source gene: JAK2

Class: DEG_APCC_DBOX_1

Location: 921:929

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6215

ASA_SCORE: 47.7333

COIL: 0.4014

CONS_SCORE: 0.4724

DSS_SCORE: 0.0557

HELIX: 0.0336

FCONS_SCORE: 0.8008

RIG_SCORE: 0.8691

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V911A	TCGA-AP-A051	UCEC	TCGA	GRRNLKLIM	DEG_APCC_DBOX_1	0.0556
p.R922W	TCGA-EA-A410	CESC	TCGA	GRRNLKLIM	DEG_APCC_DBOX_1	0.8634
p.R922W	DO49929	CESC	ICGC	GRRNLKLIM	DEG_APCC_DBOX_1	0.8634
p.D919G	DO23002	LIHC	ICGC	GRRNLKLIM	DEG_APCC_DBOX_1	0.2778
p.K926R	SIDM00845	Burkitt's Lymphoma	GDSC	GRRNLKLIM	DEG_APCC_DBOX_1	0.6126
p.Y934N	SIDM00112	Kidney Carcinoma	GDSC	GRRNLKLIM	DEG_APCC_DBOX_1	0.6389
p.Y934N	ACH-000428	Kidney Cancer	CCLE	GRRNLKLIM	DEG_APCC_DBOX_1	0.6389
p.Y934N	U031	kidney	COSMIC	GRRNLKLIM	DEG_APCC_DBOX_1	0.6389
p.K912T	SIDM00118	Colorectal Carcinoma	GDSC	GRRNLKLIM	DEG_APCC_DBOX_1	0.1944
p.K912T	ACH-001081	Colon/Colorectal Cancer	CCLE	GRRNLKLIM	DEG_APCC_DBOX_1	0.1944
p.K912T	HCC2998	large_intestine	COSMIC	GRRNLKLIM	DEG_APCC_DBOX_1	0.1944
p.R923H	SIDM01617	Endometrial Carcinoma	GDSC	GRRNLKLIM	DEG_APCC_DBOX_1	0.7133
p.R923H	ACH-000994	Endometrial/Uterine Cancer	CCLE	GRRNLKLIM	DEG_APCC_DBOX_1	0.7133
p.R923C	SIDM01409	Bladder Carcinoma	GDSC	GRRNLKLIM	DEG_APCC_DBOX_1	0.719
p.R923C	ACH-000834	Bladder Cancer	CCLE	GRRNLKLIM	DEG_APCC_DBOX_1	0.719

Drug responses associated with JAK2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	Ruxolitinib	89.3847
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	Fedratinib	3.0353
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	Lestaurtinib	1.3084
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	AZD1480	27.7657
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	AZ960	11.056
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	Ruxolitinib	427.04
SIDM00778	COREAD\|large_intestine	p.L393V (No)	GDSC	JAK_8517	723
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.S507* (No)	GDSC	Ruxolitinib	125.2459
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.S507* (No)	GDSC	Fedratinib	27.6761
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.S507* (No)	GDSC	Lestaurtinib	0.5014
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.S507* (No)	GDSC	AZD1480	3.5134
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	Ruxolitinib	93.7671
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	Fedratinib	11.3964
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	Lestaurtinib	1.0436
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	AZD1480	16.7288
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	AZ960	46.652
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	Ruxolitinib	429.63
SIDM00499	PRAD\|prostate	p.G1093R (No)	GDSC	JAK_8517	17.259
SIDM00959	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Ruxolitinib	0.083
SIDM00959	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Fedratinib	0.3524
SIDM00959	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Lestaurtinib	0.2039
SIDM00959	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	AZD1480	0.7639
SIDM00081	SKCM\|melanoma	p.E592K (No)	GDSC	Ruxolitinib	60.4198
SIDM00081	SKCM\|melanoma	p.E592K (No)	GDSC	Fedratinib	81.6498
SIDM00081	SKCM\|melanoma	p.E592K (No)	GDSC	Lestaurtinib	0.3703
SIDM00081	SKCM\|melanoma	p.E592K (No)	GDSC	AZD1480	19.2994
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	Ruxolitinib	55.5518
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	Fedratinib	10.2683
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	Lestaurtinib	0.6852
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	AZD1480	1.953
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	AZ960	1.2452
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	Ruxolitinib	39.233
SIDM00849	KIRC\|kidney	p.N337D (No)	GDSC	JAK_8517	3.1859
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Ruxolitinib	80.3165
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Fedratinib	3.3106
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Lestaurtinib	0.5978
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	AZD1480	4.6793
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	AZ960	7.107
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Ruxolitinib	89.168
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	JAK_8517	8.226
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	Ruxolitinib	348.3592
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	Fedratinib	4.7935
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	Lestaurtinib	0.4909
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	AZD1480	9.0058
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	AZ960	8.2552
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	Ruxolitinib	323.81
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V149A (No)	GDSC	JAK_8517	7.3576
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	Ruxolitinib	40.6553
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	Fedratinib	1.1552
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	Lestaurtinib	2.6546
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	AZD1480	6.0372
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	AZ960	4.5007
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	Ruxolitinib	146.77
SIDM00519	MESO\|mesothelioma	p.R1063H (No)	GDSC	JAK_8517	3.7777
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	Ruxolitinib	45.7761
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	Fedratinib	21.3955
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	Lestaurtinib	0.382
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	AZD1480	2.1472
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	AZ960	11.02
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	Ruxolitinib	111.1
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.H172R (No)	GDSC	JAK_8517	4.9186
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	Ruxolitinib	98.5833
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	Fedratinib	14.4983
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	Lestaurtinib	1.1603
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	AZD1480	4.5782
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	AZ960	10.861
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	Ruxolitinib	359.68
SIDM00781	COREAD\|large_intestine	p.F547V (No)	GDSC	JAK_8517	74.535
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	Ruxolitinib	74.5684
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	Fedratinib	12.0349
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	Lestaurtinib	0.5979
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	AZD1480	5.529
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	AZ960	8.1198
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	Ruxolitinib	85.21
SIDM00146	BRCA\|breast	p.S411N (No)	GDSC	JAK_8517	70.043
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Ruxolitinib	170.1433
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Fedratinib	332.4937
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Lestaurtinib	4.7116
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	AZD1480	62.6019
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	AZ960	301.27
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	Ruxolitinib	275.4
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.L393V (No)	GDSC	JAK_8517	81.082
SIDM00126	SKCM\|melanoma	p.F560L (No)	GDSC	Ruxolitinib	206.1708
SIDM00126	SKCM\|melanoma	p.F560L (No)	GDSC	Fedratinib	192.8503
SIDM00126	SKCM\|melanoma	p.F560L (No)	GDSC	Lestaurtinib	1.0552
SIDM00126	SKCM\|melanoma	p.F560L (No)	GDSC	AZD1480	21.1877
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	Ruxolitinib	90.4634
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	Fedratinib	2.5064
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	Lestaurtinib	0.2653
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	AZD1480	3.3395
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	AZ960	2.5702
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	Ruxolitinib	212.56
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.R1063H (No)	GDSC	JAK_8517	5.7814
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	Ruxolitinib	65.8124
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	Fedratinib	48.9221
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	Lestaurtinib	0.0588
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	AZD1480	3.9166
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	AZ960	101.69
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	Ruxolitinib	151.55
SIDM01088	UNCLASSIFIED\|endometrium	p.F85S (No)	GDSC	JAK_8517	176.2
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	Ruxolitinib	17.3702
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	Fedratinib	3.1807
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	Lestaurtinib	4.0816
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	AZD1480	2.0346
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	AZ960	4.0509
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	Ruxolitinib	129.23
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.R1117M (No)	GDSC	JAK_8517	33.581
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	Ruxolitinib	44.7185
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	Fedratinib	7.6978
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	Lestaurtinib	0.1207
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	AZD1480	1.3611
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	AZ960	3.4864
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	Ruxolitinib	145.32
SIDM00998	GBM\|glioma	p.R1063H (No)	GDSC	JAK_8517	23.471
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	Ruxolitinib	103.4205
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	Fedratinib	7.0448
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	Lestaurtinib	0.1701
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	AZD1480	8.859
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	AZ960	85.248
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	Ruxolitinib	344.74
SIDM00483	ESCA\|oesophagus	p.L393V (No)	GDSC	JAK_8517	223.99
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	Ruxolitinib	39.0824
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	Fedratinib	10.6946
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	Lestaurtinib	0.0765
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	AZD1480	3.0493
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	AZ960	19.068
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	Ruxolitinib	71.095
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.I67M (No)	GDSC	JAK_8517	97.53
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	Ruxolitinib	23.5764
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	Fedratinib	5.1138
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	Lestaurtinib	35.1278
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	AZD1480	7.7606
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	AZ960	50.974
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	Ruxolitinib	73.193
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.N337D (No)	GDSC	JAK_8517	84.154
SIDM00112	KIRC\|kidney	p.Y934N (Yes)	GDSC	Ruxolitinib	44.8949
SIDM00112	KIRC\|kidney	p.Y934N (Yes)	GDSC	Fedratinib	6.5895
SIDM00112	KIRC\|kidney	p.Y934N (Yes)	GDSC	Lestaurtinib	21.5783
SIDM00112	KIRC\|kidney	p.Y934N (Yes)	GDSC	AZD1480	2.6537
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	Ruxolitinib	162.2044
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	Fedratinib	33.5601
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	Lestaurtinib	2.4851
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	AZD1480	9.5951
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	AZ960	52.453
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	Ruxolitinib	117.96
SIDM01045	UCEC\|endometrium	p.F537L (No)	GDSC	JAK_8517	47.734
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	Ruxolitinib	162.2044
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	Fedratinib	33.5601
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	Lestaurtinib	2.4851
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	AZD1480	9.5951
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	AZ960	52.453
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	Ruxolitinib	117.96
SIDM01045	UCEC\|endometrium	p.V984A (No)	GDSC	JAK_8517	47.734
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	Ruxolitinib	0.9102
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	Fedratinib	1.8244
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	Lestaurtinib	0.0578
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	AZD1480	0.1235
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	AZ960	0.0511
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	Ruxolitinib	0.1837
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.C675W (No)	GDSC	JAK_8517	0.3404
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	Ruxolitinib	56.0716
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	Fedratinib	32.7952
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	Lestaurtinib	0.8513
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	AZD1480	3.9152
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	AZ960	59.233
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	Ruxolitinib	168.77
SIDM00333	UCEC\|endometrium	p.L634P (No)	GDSC	JAK_8517	55.4
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.E846D (No)	GDSC	Ruxolitinib	50.4603
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.E846D (No)	GDSC	Fedratinib	110.7556
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.E846D (No)	GDSC	Lestaurtinib	0.7169
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.E846D (No)	GDSC	AZD1480	5.8896
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	Ruxolitinib	175.2455
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	Fedratinib	3.2616
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	AZD1480	30.6756
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	AZ960	81.595
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	Ruxolitinib	368.52
SIDM00217	COREAD\|large_intestine	p.V563I (No)	GDSC	JAK_8517	15.843
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	Ruxolitinib	175.2455
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	Fedratinib	3.2616
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	AZD1480	30.6756
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	AZ960	81.595
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	Ruxolitinib	368.52
SIDM00217	COREAD\|large_intestine	p.R1063C (No)	GDSC	JAK_8517	15.843
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	Ruxolitinib	175.2455
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	Fedratinib	3.2616
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	AZD1480	30.6756
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	AZ960	81.595
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	Ruxolitinib	368.52
SIDM00217	COREAD\|large_intestine	p.D1128N (No)	GDSC	JAK_8517	15.843
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	Ruxolitinib	175.2455
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	Fedratinib	3.2616
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	AZD1480	30.6756
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	AZ960	81.595
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	Ruxolitinib	368.52
SIDM00217	COREAD\|large_intestine	p.N1129S (No)	GDSC	JAK_8517	15.843
SIDM01165	PAAD\|pancreas	p.T108A (No)	GDSC	Ruxolitinib	104.6344
SIDM01165	PAAD\|pancreas	p.T108A (No)	GDSC	Fedratinib	222.2218
SIDM01165	PAAD\|pancreas	p.T108A (No)	GDSC	Lestaurtinib	1.2649
SIDM01165	PAAD\|pancreas	p.T108A (No)	GDSC	AZD1480	9.525
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	Ruxolitinib	139.6993
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	Fedratinib	23.5551
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	Lestaurtinib	29.8144
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	AZD1480	17.8163
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	AZ960	38.792
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	Ruxolitinib	243.11
SIDM00758	LUAD\|lung_NSCLC_adenocarcinoma	p.R426* (No)	GDSC	JAK_8517	392.71
SIDM00637	DLBC\|B_cell_lymphoma	p.P811T (No)	GDSC	Ruxolitinib	16.1078
SIDM00637	DLBC\|B_cell_lymphoma	p.P811T (No)	GDSC	Fedratinib	7.39
SIDM00637	DLBC\|B_cell_lymphoma	p.P811T (No)	GDSC	Lestaurtinib	0.3239
SIDM00637	DLBC\|B_cell_lymphoma	p.P811T (No)	GDSC	AZD1480	3.3364
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	Ruxolitinib	70.6163
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	Fedratinib	7.7157
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	Lestaurtinib	0.3509
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	AZD1480	4.5425
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	AZ960	16.765
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	Ruxolitinib	316.09
SIDM00660	COREAD\|large_intestine	p.T7M (No)	GDSC	JAK_8517	13.618
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	Ruxolitinib	70.6163
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	Fedratinib	7.7157
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	Lestaurtinib	0.3509
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	AZD1480	4.5425
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	AZ960	16.765
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	Ruxolitinib	316.09
SIDM00660	COREAD\|large_intestine	p.R1063H (No)	GDSC	JAK_8517	13.618
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	Ruxolitinib	99.361
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	Fedratinib	206.2358
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	Lestaurtinib	0.9004
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	AZD1480	4.7886
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	AZ960	114.36
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	Ruxolitinib	70.874
SIDM00238	OV\|ovary	p.L437fs*1 (No)	GDSC	JAK_8517	20.127
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	Ruxolitinib	39.8011
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	Fedratinib	2.8302
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	Lestaurtinib	0.4145
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	AZD1480	2.7885
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	AZ960	1.1807
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	Ruxolitinib	14.638
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L393V (No)	GDSC	JAK_8517	4.6046
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	Ruxolitinib	47.9086
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	Fedratinib	10.3883
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	Lestaurtinib	0.4407
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	AZD1480	7.383
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	AZ960	25.262
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	Ruxolitinib	208.27
SIDM00517	UNCLASSIFIED\|head_and_neck	p.S797C (No)	GDSC	JAK_8517	71.369
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	Ruxolitinib	0.8366
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	Fedratinib	0.5216
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	Lestaurtinib	0.1083
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	AZD1480	0.8102
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	AZ960	0.8081
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	Ruxolitinib	14.106
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y96H (No)	GDSC	JAK_8517	3.7124
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	Ruxolitinib	81.5868
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	Fedratinib	31.1025
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	Lestaurtinib	0.1456
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	AZD1480	29.3183
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	AZ960	1.4145
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	Ruxolitinib	154.69
SIDM00789	COREAD\|large_intestine	p.L383P (No)	GDSC	JAK_8517	6.4894
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	Ruxolitinib	43.8231
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	Fedratinib	30.0579
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	Lestaurtinib	1.2424
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	AZD1480	5.3201
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	AZ960	6.8354
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	Ruxolitinib	163.57
SIDM00534	COREAD\|large_intestine	p.D194N (No)	GDSC	JAK_8517	7.2298
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	Ruxolitinib	43.8231
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	Fedratinib	30.0579
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	Lestaurtinib	1.2424
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	AZD1480	5.3201
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	AZ960	6.8354
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	Ruxolitinib	163.57
SIDM00534	COREAD\|large_intestine	p.D319N (No)	GDSC	JAK_8517	7.2298
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	Ruxolitinib	42.1063
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	Fedratinib	2.7243
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	Lestaurtinib	0.6164
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	AZD1480	3.4375
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	AZ960	15.223
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	Ruxolitinib	176.91
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N337D (No)	GDSC	JAK_8517	28.769
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	Ruxolitinib	82.7252
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	Fedratinib	12.5911
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	Lestaurtinib	2.0013
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	AZD1480	6.894
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	AZ960	211.86
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	Ruxolitinib	255.89
SIDM00092	OV\|ovary	p.L393V (No)	GDSC	JAK_8517	260.42
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Ruxolitinib	72.3881
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Fedratinib	9.0164
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Lestaurtinib	1.5206
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	AZD1480	4.4928
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	AZ960	5.251
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Ruxolitinib	283.36
SIDM01127	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	JAK_8517	11.47
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	Ruxolitinib	27.8232
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	Fedratinib	4.085
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	Lestaurtinib	0.697
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	AZD1480	7.1235
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	AZ960	2.8096
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	Ruxolitinib	183.24
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.H606Q (No)	GDSC	JAK_8517	4.2224
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	Ruxolitinib	19.1313
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	Fedratinib	1.333
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	Lestaurtinib	0.4766
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	AZD1480	22.1725
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	AZ960	5.9361
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	Ruxolitinib	69.592
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.L905P (No)	GDSC	JAK_8517	4.4151
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Ruxolitinib	113.388
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Fedratinib	78.007
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Lestaurtinib	2.8468
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	AZD1480	4.0132
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	AZ960	9.0229
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	Ruxolitinib	44.072
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N1108S (No)	GDSC	JAK_8517	31.538
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	Ruxolitinib	63.1377
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	Fedratinib	5.4308
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	Lestaurtinib	2.5578
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	AZD1480	8.2247
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	AZ960	55.429
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	Ruxolitinib	65.156
SIDM00621	UNCLASSIFIED\|ewings_sarcoma	p.L393V (No)	GDSC	JAK_8517	77.239
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	Ruxolitinib	49.0679
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	Fedratinib	6.0361
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	Lestaurtinib	0.2443
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	AZD1480	5.44
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	AZ960	0.9218
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	Ruxolitinib	26.012
SIDM01097	UNCLASSIFIED\|ewings_sarcoma	p.S797C (No)	GDSC	JAK_8517	4.1945
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	Ruxolitinib	15.3566
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	Fedratinib	9.2234
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	Lestaurtinib	10.3419
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	AZD1480	8.8272
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	AZ960	58.808
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	Ruxolitinib	410.94
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.W157* (No)	GDSC	JAK_8517	31.335
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	Ruxolitinib	78.2741
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	Fedratinib	16.6053
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	Lestaurtinib	0.7629
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	AZD1480	2.5873
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	AZ960	5.123
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	Ruxolitinib	242.24
SIDM00490	GBM\|glioma	p.R1063H (No)	GDSC	JAK_8517	11.822
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Ruxolitinib	0.664
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Fedratinib	1.0272
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Lestaurtinib	0.2476
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	AZD1480	1.2949
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	AZ960	0.5605
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	Ruxolitinib	3.585
SIDM00594	LAML\|acute_myeloid_leukaemia	p.V617F (No)	GDSC	JAK_8517	2.4584
SIDM00892	BRCA\|breast	p.L393V (No)	GDSC	Ruxolitinib	319.8362
SIDM00892	BRCA\|breast	p.L393V (No)	GDSC	Fedratinib	474.3251
SIDM00892	BRCA\|breast	p.L393V (No)	GDSC	Lestaurtinib	11.6027
SIDM00892	BRCA\|breast	p.L393V (No)	GDSC	AZD1480	123.4454
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	Ruxolitinib	78.1266
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	Fedratinib	194.2755
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	Lestaurtinib	0.9478
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	AZD1480	19.8899
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	AZ960	63.055
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	Ruxolitinib	192.44
SIDM00105	OV\|ovary	p.R1063H (No)	GDSC	JAK_8517	162.26
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	Ruxolitinib	99.361
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	Fedratinib	206.2358
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	Lestaurtinib	0.9004
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	AZD1480	4.7886
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	AZ960	114.36
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	Ruxolitinib	70.874
SIDM00238	OV\|ovary	p.Y42H (No)	GDSC	JAK_8517	20.127
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	Ruxolitinib	62.3457
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	Fedratinib	18.8935
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	Lestaurtinib	3.0943
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	AZD1480	4.2583
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	AZ960	8.9025
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	Ruxolitinib	142.83
SIDM00118	COREAD\|large_intestine	p.N691H (No)	GDSC	JAK_8517	24.923
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	Ruxolitinib	62.3457
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	Fedratinib	18.8935
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	Lestaurtinib	3.0943
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	AZD1480	4.2583
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	AZ960	8.9025
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	Ruxolitinib	142.83
SIDM00118	COREAD\|large_intestine	p.K912T (Yes)	GDSC	JAK_8517	24.923

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRRNLKLIM

Degron related mutations and impact score

Drug responses associated with JAK2 mutations

All proteins holding degron of GRRNLKLIM

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60674	Tyrosine-protein kinase JAK2	DEG_APCC_DBOX_1	921:929	GRRNLKLIM	APC,CDC20,FZR1	0.6215	More...