DegronMD

Uniprot ID: P59044

Source protein: NACHT, LRR and PYD domains-containing protein 6

Source gene: NLRP6

Class: DEG_APCC_DBOX_1

Location: 192:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6454

ASA_SCORE: 45.4556

COIL: 0.428

CONS_SCORE: 0.4378

DSS_SCORE: 0.417

HELIX: 0.0057

FCONS_SCORE: 0.8844

RIG_SCORE: 0.7898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D189E	DO228787	GACA	ICGC	GRRPLTVVL	DEG_APCC_DBOX_1	0.25
p.G207S	DO229259	THCA	ICGC	GRRPLTVVL	DEG_APCC_DBOX_1	0.1389
p.R188S	DO229221	THCA	ICGC	GRRPLTVVL	DEG_APCC_DBOX_1	0.2222
p.R187H	SIDM00863	Burkitt's Lymphoma	GDSC	GRRPLTVVL	DEG_APCC_DBOX_1	0.1944
p.R187H	SIDM00774	Breast Carcinoma	GDSC	GRRPLTVVL	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_APCC_DBOX_1	192:200	GRRPLTVVL	APC,CDC20,FZR1	0.6454	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons