DegronMD

Uniprot ID: Q8NE86

Source protein: Calcium uniporter protein, mitochondrial

Source gene: MCU

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7208

ASA_SCORE: 83.8889

COIL: 0.4383

CONS_SCORE: 0.4486

DSS_SCORE: 0.2406

HELIX: 0.4771

FCONS_SCORE: 1.2243

RIG_SCORE: 0.8357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A4T	TCGA-2W-A8YY	CESC	TCGA	GRSLLLLLS	DEG_APCC_DBOX_1	0.7222
p.A4T	DO223732	CESC	ICGC	GRSLLLLLS	DEG_APCC_DBOX_1	0.7222
p.G18A	TCGA-VQ-A8P2	STAD	TCGA	GRSLLLLLS	DEG_APCC_DBOX_1	0.2222
p.G18A	DO51761	STAD	ICGC	GRSLLLLLS	DEG_APCC_DBOX_1	0.2222
p.W9L	DO229036	LICA	ICGC	GRSLLLLLS	DEG_APCC_DBOX_1	0.7015
p.R5M	DO231155	LUSC	ICGC	GRSLLLLLS	DEG_APCC_DBOX_1	0.75
p.L12F	ACH-000997	Colon/Colorectal Cancer	CCLE	GRSLLLLLS	DEG_APCC_DBOX_1	0.587
p.S23P	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	GRSLLLLLS	DEG_APCC_DBOX_1	0.0833
p.S23P	KON	upper_aerodigestive_tract	COSMIC	GRSLLLLLS	DEG_APCC_DBOX_1	0.0833
p.S23P	SBC-3	lung	COSMIC	GRSLLLLLS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NE86	Calcium uniporter protein, mitochondrial	DEG_APCC_DBOX_1	6:14	GRSLLLLLS	APC,CDC20,FZR1	0.7208	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons