DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GRSNLPDVS
Uniprot ID:
Q8WZB0
Source protein:
Putative uncharacterized protein ERCC6L2-AS1
Source gene:
ERCC6L2-AS1
Class:
DEG_APCC_DBOX_1
Location:
126:134
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8024
ASA_SCORE:
70.2222
COIL:
0.7586
CONS_SCORE:
0
DSS_SCORE:
0.5223
HELIX:
0.1812
FCONS_SCORE:
0
RIG_SCORE:
0.7217
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERCC6L2-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRSNLPDVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8WZB0
Putative uncharacterized protein ERCC6L2-AS1
DEG_APCC_DBOX_1
126:134
GRSNLPDVS
APC,CDC20,FZR1
0.8024
More...