DegronMD

Uniprot ID: Q7Z5Q1

Source protein: Cytoplasmic polyadenylation element-binding protein 2

Source gene: CPEB2

Class: DEG_APCC_DBOX_1

Location: 289:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9164

ASA_SCORE: 64.5889

COIL: 0.8566

CONS_SCORE: 0.414

DSS_SCORE: 0.2838

HELIX: 0.0533

FCONS_SCORE: 1.2179

RIG_SCORE: 0.7591

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290H	ACH-001443	Thyroid Cancer	CCLE	GRSSLFPID	DEG_APCC_DBOX_1	0.8244
p.R290H	ASH-3	thyroid	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.8244
p.R302C	SNU-407	large_intestine	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.1944
p.R298H	ASH-3	thyroid	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.3056
p.R299C	SNU-407	large_intestine	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.2778
p.R307C	SNU-407	large_intestine	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.0556
p.R294Q	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	GRSSLFPID	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z5Q1	Cytoplasmic polyadenylation element-binding protein 2	DEG_APCC_DBOX_1	289:297	GRSSLFPID	APC,CDC20,FZR1	0.9164	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons