DegronMD

Uniprot ID: Q96BA8

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 1

Source gene: CREB3L1

Class: DEG_APCC_DBOX_1

Location: 438:446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7509

ASA_SCORE: 84.3333

COIL: 0.89

CONS_SCORE: 0.3163

DSS_SCORE: 0.5808

HELIX: 0.0886

FCONS_SCORE: 1.0122

RIG_SCORE: 0.7009

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W435R	TCGA-19-2631	GBM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.25
p.W435R	DO13809	GBM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.25
p.G456V	TCGA-86-8358	LUAD	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.0556
p.G456V	DO25471	LUAD	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.0556
p.E436K	TCGA-BF-A1Q0	SKCM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.2778
p.E436K	DO47374	SKCM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.2778
p.A432V	TCGA-CV-7242	HNSC	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.A432V	DO14974	HNSC	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	TCGA-EB-A85I	SKCM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	TCGA-EE-A2GC	SKCM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	DO37839	SKCM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	DO50296	SKCM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	ACH-001362	Lung Cancer	CCLE	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.E452K	NCI-H1770	lung	COSMIC	GRSTLLPME	DEG_APCC_DBOX_1	0.1667
p.S440N	TCGA-EE-A2GO	SKCM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.5958
p.S440N	DO37823	SKCM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.5958
p.L442M	TCGA-FS-A1ZR	SKCM	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.711
p.L442M	DO37651	SKCM	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.711
p.R439C	TCGA-G4-6586	COAD	TCGA	GRSTLLPME	DEG_APCC_DBOX_1	0.8301
p.R439C	DO9698	COAD	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.8301
p.G456R	DO233634	GACA	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.0556
p.G433V	DO229037	LICA	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.1944
p.P448Q	DO218773	ORCA	ICGC	GRSTLLPME	DEG_APCC_DBOX_1	0.2778
p.D449Y	SIDM00697	Small Cell Lung Carcinoma	GDSC	GRSTLLPME	DEG_APCC_DBOX_1	0.25
p.D449Y	ACH-000830	Lung Cancer	CCLE	GRSTLLPME	DEG_APCC_DBOX_1	0.25
p.D449Y	NCI-H1436	lung	COSMIC	GRSTLLPME	DEG_APCC_DBOX_1	0.25
p.M445V	SIDM01112	Osteosarcoma	GDSC	GRSTLLPME	DEG_APCC_DBOX_1	0.6097

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRSTLLPME

Degron related mutations and impact score

Drug responses associated with CREB3L1 mutations

All proteins holding degron of GRSTLLPME

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_APCC_DBOX_1	438:446	GRSTLLPME	APC,CDC20,FZR1	0.7509	More...