DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
GRTPLRIVG
Uniprot ID:
Q7Z5A4
Source protein:
Putative serine protease 42
Source gene:
PRSS42P
Class:
DEG_APCC_DBOX_1
Location:
74:82
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6537
ASA_SCORE:
49.8333
COIL:
0.6098
CONS_SCORE:
0.5398
DSS_SCORE:
0.3191
HELIX:
0.0086
FCONS_SCORE:
1.0385
RIG_SCORE:
0.8177
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PRSS42P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRTPLRIVG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z5A4
Putative serine protease 42
DEG_APCC_DBOX_1
74:82
GRTPLRIVG
APC,CDC20,FZR1
0.6537
More...