DegronMD

Uniprot ID: Q14697

Source protein: Neutral alpha-glucosidase AB

Source gene: GANAB

Class: DEG_APCC_TPR_1

Location: 942:944

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6166

ASA_SCORE: 104.9333

COIL: 0.3773

CONS_SCORE: 0.3231

DSS_SCORE: 0.6837

HELIX: 0.0037

FCONS_SCORE: 0.7895

RIG_SCORE: 0.8372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G954V	TCGA-66-2793	LUSC	TCGA	HLR	DEG_APCC_TPR_1	0.0556
p.G954V	DO27334	LUSC	ICGC	HLR	DEG_APCC_TPR_1	0.0556
p.R951C	TCGA-AG-3906	READ	TCGA	HLR	DEG_APCC_TPR_1	0.1389
p.R951C	DO36491	READ	ICGC	HLR	DEG_APCC_TPR_1	0.1389
p.R951H	TCGA-AZ-4315	COAD	TCGA	HLR	DEG_APCC_TPR_1	0.1389
p.R951H	DO8842	COAD	ICGC	HLR	DEG_APCC_TPR_1	0.1389
p.R951H	DO232761	PBCA	ICGC	HLR	DEG_APCC_TPR_1	0.1389
p.S938P	TCGA-IB-7651	PAAD	TCGA	HLR	DEG_APCC_TPR_1	0.2222
p.S938P	DO46657	PAAD	ICGC	HLR	DEG_APCC_TPR_1	0.2222
p.H941R	DO45289	LIRI	ICGC	HLR	DEG_APCC_TPR_1	0.3056
p.S938F	DO220891	MELA	ICGC	HLR	DEG_APCC_TPR_1	0.2222
p.S937Y	NCI-H647	lung	COSMIC	HLR	DEG_APCC_TPR_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14697	Neutral alpha-glucosidase AB	DEG_APCC_TPR_1	942:944	HLR	APC,CDC20,FZR1	0.6166	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons