DegronMD

Uniprot ID: Q92508

Source protein: Piezo-type mechanosensitive ion channel component 1

Source gene: PIEZO1

Class: DEG_APCC_DBOX_1

Location: 1561:1569

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5666

ASA_SCORE: 66.2333

COIL: 0.3773

CONS_SCORE: 0.4055

DSS_SCORE: 0.4055

HELIX: 0.5318

FCONS_SCORE: 1.2124

RIG_SCORE: 0.7944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1559K	TCGA-AA-3984	COAD	TCGA	HRGVLDQLY	DEG_APCC_DBOX_1	0.2778
p.E1559K	DO222421	BTCA	ICGC	HRGVLDQLY	DEG_APCC_DBOX_1	0.2778
p.E1559K	DO9002	COAD	ICGC	HRGVLDQLY	DEG_APCC_DBOX_1	0.2778
p.A1575V	TCGA-BH-A18G	BRCA	TCGA	HRGVLDQLY	DEG_APCC_DBOX_1	0.1667
p.A1575V	DO3686	BRCA	ICGC	HRGVLDQLY	DEG_APCC_DBOX_1	0.1667
p.P1578S	TCGA-CK-4951	COAD	TCGA	HRGVLDQLY	DEG_APCC_DBOX_1	0.0833
p.P1578S	DO10582	COAD	ICGC	HRGVLDQLY	DEG_APCC_DBOX_1	0.0833
p.G1579C	ACH-001061	Colon/Colorectal Cancer	CCLE	HRGVLDQLY	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92508	Piezo-type mechanosensitive ion channel component 1	DEG_APCC_DBOX_1	1561:1569	HRGVLDQLY	APC,CDC20,FZR1	0.5666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons