DegronMD

Uniprot ID: O15534

Source protein: Period circadian protein homolog 1

Source gene: PER1

Class: DEG_APCC_DBOX_1

Location: 494:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6784

ASA_SCORE: 89.4111

COIL: 0.5213

CONS_SCORE: 0.5828

DSS_SCORE: 0.5319

HELIX: 0.4219

FCONS_SCORE: 1.4114

RIG_SCORE: 0.7394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I486L	TCGA-A5-A2K5	UCEC	TCGA	HRLLLQPVH	DEG_APCC_DBOX_1	0.1111
p.I493T	TCGA-AR-A0TT	BRCA	TCGA	HRLLLQPVH	DEG_APCC_DBOX_1	0.3056
p.V512D	DO233005	GACA	ICGC	HRLLLQPVH	DEG_APCC_DBOX_1	0.0556
p.G493S	DO38380	STAD	ICGC	HRLLLQPVH	DEG_APCC_DBOX_1	0.3056
p.V501I	SIDM01619	Endometrial Carcinoma	GDSC	HRLLLQPVH	DEG_APCC_DBOX_1	0.5965
p.G497V	HCC202	breast	COSMIC	HRLLLQPVH	DEG_APCC_DBOX_1	0.7532
p.G493V	HCC202	breast	COSMIC	HRLLLQPVH	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15534	Period circadian protein homolog 1	DEG_APCC_DBOX_1	494:502	HRLLLQPVH	APC,CDC20,FZR1	0.6784	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons