DegronMD

Uniprot ID: O15055

Source protein: Period circadian protein homolog 2

Source gene: PER2

Class: DEG_APCC_DBOX_1

Location: 467:475

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8868

ASA_SCORE: 89.9556

COIL: 0.5458

CONS_SCORE: 0.5802

DSS_SCORE: 0.5169

HELIX: 0.3896

FCONS_SCORE: 1.3869

RIG_SCORE: 0.7465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P473S	TCGA-VS-A8EL	CESC	TCGA	HRLLLQPVP	DEG_APCC_DBOX_1	0.5641
p.S458T	DO50332	ESAD	ICGC	HRLLLQPVP	DEG_APCC_DBOX_1	0.0833
p.I466N	DO233942	GACA	ICGC	HRLLLQPVP	DEG_APCC_DBOX_1	0.3056
p.L485P	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	HRLLLQPVP	DEG_APCC_DBOX_1	0.0556
p.L485P	ACH-000837	Lung Cancer	CCLE	HRLLLQPVP	DEG_APCC_DBOX_1	0.0556
p.L485P	NCI-H322M	lung	COSMIC	HRLLLQPVP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15055	Period circadian protein homolog 2	DEG_APCC_DBOX_1	467:475	HRLLLQPVP	APC,CDC20,FZR1	0.8868	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons