DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
HRPNLSGIP
Uniprot ID:
Q8NDB6
Source protein:
Protein FAM156A/FAM156B
Source gene:
FAM156A; FAM156B
Class:
DEG_APCC_DBOX_1
Location:
134:142
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9083
ASA_SCORE:
71.7222
COIL:
0.8863
CONS_SCORE:
0.693
DSS_SCORE:
0.4231
HELIX:
0.0663
FCONS_SCORE:
1.028
RIG_SCORE:
0.638
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM156A; FAM156B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of HRPNLSGIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NDB6
Protein FAM156A/FAM156B
DEG_APCC_DBOX_1
134:142
HRPNLSGIP
APC,CDC20,FZR1
0.9083
More...