DegronMD

Uniprot ID: Q5T1R4

Source protein: Transcription factor HIVEP3

Source gene: HIVEP3

Class: DEG_APCC_DBOX_1

Location: 1542:1550

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9921

ASA_SCORE: 107.0889

COIL: 0.9329

CONS_SCORE: 0.5588

DSS_SCORE: 0.7574

HELIX: 0.0186

FCONS_SCORE: 1.0813

RIG_SCORE: 0.6117

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1555E	TCGA-D1-A103	UCEC	TCGA	HRRGLTPLS	DEG_APCC_DBOX_1	0.1944
p.D1555E	DO42312	UCEC	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.1944
p.E1533K	TCGA-W3-A825	SKCM	TCGA	HRRGLTPLS	DEG_APCC_DBOX_1	0.0833
p.E1533K	DO51272	SKCM	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.0833
p.P1535L	TCGA-YD-A9TB	SKCM	TCGA	HRRGLTPLS	DEG_APCC_DBOX_1	0.1389
p.P1535L	DO51297	SKCM	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.1389
p.L1546V	DO222790	COCA	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.6765
p.L1546V	SIDM01575	Plasma Cell Myeloma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.6765
p.L1546V	ACH-000426	Myeloma	CCLE	HRRGLTPLS	DEG_APCC_DBOX_1	0.6765
p.P1537L	DO222702	MELA	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.1944
p.G1545V	DO51148	PRAD	ICGC	HRRGLTPLS	DEG_APCC_DBOX_1	0.6421
p.E1533G	SIDM01090	Colorectal Carcinoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.0833
p.E1533G	ACH-000943	Colon/Colorectal Cancer	CCLE	HRRGLTPLS	DEG_APCC_DBOX_1	0.0833
p.E1533G	RKO	large_intestine	COSMIC	HRRGLTPLS	DEG_APCC_DBOX_1	0.0833
p.V1551M	SIDM00543	Melanoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.3056
p.V1551M	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.3056
p.V1551M	SIDM00279	Gastric Carcinoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.3056
p.V1551M	SIDM01578	Bladder Carcinoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.3056
p.R1544S	SIDM01664	Prostate Carcinoma	GDSC	HRRGLTPLS	DEG_APCC_DBOX_1	0.6316
p.R1544S	ACH-000952	Prostate Cancer	CCLE	HRRGLTPLS	DEG_APCC_DBOX_1	0.6316
p.R1543Q	ACH-001786	Colon/Colorectal Cancer	CCLE	HRRGLTPLS	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T1R4	Transcription factor HIVEP3	DEG_APCC_DBOX_1	1542:1550	HRRGLTPLS	APC,CDC20,FZR1	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons